EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.55 | additional information | not activated by 0.025 mM 2-naphthoflavone | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.55 | cimetidine | - |
Homo sapiens | |
1.14.14.55 | diltiazem | - |
Homo sapiens | |
1.14.14.55 | doxycycline | - |
Homo sapiens | |
1.14.14.55 | erythromycin | - |
Homo sapiens | |
1.14.14.55 | hydralazine | - |
Homo sapiens | |
1.14.14.55 | ketoconazole | - |
Homo sapiens | |
1.14.14.55 | additional information | not inhibited by lignocaine, pyrimethamine, dapsone, chloroquine, diazepam, norfloxacin, proguanil, cycloguanil, and 4-chlorophenylbiguanide | Homo sapiens | |
1.14.14.55 | nifepidine | - |
Homo sapiens | |
1.14.14.55 | oleandomycin | - |
Homo sapiens | |
1.14.14.55 | Omeprazole | - |
Homo sapiens | |
1.14.14.55 | primaquine | - |
Homo sapiens | |
1.14.14.55 | tetracycline | - |
Homo sapiens | |
1.14.14.55 | troleandomycin | - |
Homo sapiens | |
1.14.14.55 | verapamil | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.14.55 | microsome | - |
Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.55 | quinine + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.55 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.55 | liver | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.55 | quinine + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.55 | tacrolimus + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.55 | CYP3A4 | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.14.14.55 | 0.000026 | - |
at pH 7.4 and 37°C | Homo sapiens | ketoconazole | |
1.14.14.55 | 0.0083 | - |
at pH 7.4 and 37°C | Homo sapiens | troleandomycin | |
1.14.14.55 | 0.017 | - |
at pH 7.4 and 37°C | Homo sapiens | doxycycline | |
1.14.14.55 | 0.018 | - |
at pH 7.4 and 37°C | Homo sapiens | Omeprazole | |
1.14.14.55 | 0.02 | - |
at pH 7.4 and 37°C | Homo sapiens | primaquine | |
1.14.14.55 | 0.029 | - |
at pH 7.4 and 37°C | Homo sapiens | tetracycline | |
1.14.14.55 | 0.038 | - |
at pH 7.4 and 37°C | Homo sapiens | nifepidine | |
1.14.14.55 | 0.061 | - |
at pH 7.4 and 37°C | Homo sapiens | erythromycin | |
1.14.14.55 | 0.064 | - |
at pH 7.4 and 37°C | Homo sapiens | verapamil | |
1.14.14.55 | 0.097 | - |
at pH 7.4 and 37°C | Homo sapiens | cimetidine | |
1.14.14.55 | 0.127 | - |
at pH 7.4 and 37°C | Homo sapiens | diltiazem | |
1.14.14.55 | 0.143 | - |
at pH 7.4 and 37°C | Homo sapiens | oleandomycin | |
1.14.14.55 | 0.197 | - |
at pH 7.4 and 37°C | Homo sapiens | hydralazine |